This international, multi-center prospective study aimed to assess dolutegravir adherence patterns associated with viremia.  Participants received triple therapy, and three subgroups were examined: (a) ARV-naïve PWH; (b) treatment-experienced PWH undergoing regimen modification due to virologic failure; and (c) virologically suppressed PWH undergoing regimen switch.  Participants were followed with electronic adherence monitoring; results were compared to raltegravir-, boosted PI-, or NNRTI-anchored combinations.  At 6 months, 92% of participants on dolutegravir had VL ≤50 copies/mL.  The proportion of subgroup participants with VL between 51 and 200 copies/mL were: 8% for ARV-naïve participants; 17% for participants with prior virologic failure; and 2% for the switch subgroup.  For participants with low-level viremia and successful genotype sequencing, no INSTI mutations were found.  Adherence pattern to dolutegravir-based therapy did not predict virologic suppression; this was in strong contrast to older regimens.  Further, dolutegravir use was significantly and independently associated with lower risk of viremia compared to other ARVs in participants with lower (≤95%) adherence levels.  Investigators concluded that dolutegravir-based triple therapy appears to be more forgiving [over the short-term] to missed doses, either by average adherence or treatment interruptions, compared to older ARVs.  Risk of viremia was consistent with the previously suggested >80% level of average adherence reported in other studies.