Due to the effectiveness of antiretroviral therapy (ART) most persons with HIV (PWH) are achieving normal lifespans but not normal or healthy aging. A higher-than-expected rate of coinfections, comorbidities and complications (CCC) which are worsened by stigma, poverty, and isolation have been found in PWH. To address the research needs for HIV-associated CCC, the NIH brought together 96 medical experts and community advocates. From this group of individuals, five working groups (WG) participated in a year-long process of assessing the “state of the art” regarding numerous aspects of HIV care. It was the responsibility of the WGs to select 3 to 5 priority topics for presentation and discussion. The NIH then held a 2-day CCC workshop (HIV ACTION) that included over 400 participants. The format included general and individual WG presentations and discussions. Priority lists of vital research issues were presented by the co-chairs of each WG. The NIH planning committee identified six key areas of research: epidemiology and population including aging with HIV; pathogenesis and basic science that includes immunopathogenesis; clinical research that includes comorbidity management; implementation science; syndemics research including HIV-infectious syndemics; and international research in low- and middle-income countries that consist of research needs and curricular training in HIV/AIDS comorbidities. Going forward, the participants in the HIV workshop emphasized the need for “collaborative efforts of many disciplines” to implement this ambitious research agenda needed to improve the health and wellbeing for persons with HIV.