The Art and Science of Resistance: Fundamentals of HIV Resistance

Release date: May 13, 2020

Expiration date: May 13, 2021

Estimated time to complete activity: 2 hours

This event is jointly provided by Postgraduate Institute for Medicine and the American Academy of HIV Medicine.
This activity is supported by independent education grants from Merck, Inc. and ViiV Healthcare.
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Target Audience
This activity has been designed to meet the educational needs of physicians, physician assistants, nurse practitioners, registered nurses and pharmacists.

Educational Objectives
After completing this activity, the participant should be better able to:
  • Recommend, review and interpret the various viral resistance tests (e.g. genotype, phenotype, co-rector tropism) currently available for patient management
  • Review the nomenclature for resistance mutations
  • Describe the mechanisms of resistance for each class of antiretroviral drugs
  • Discuss concepts of UCCO, LCCO, BCO, 1C50, FC, RC, archived resistance, cross resistance and transmitted resistance
  • Recommend an optimal treatment regimen of patients who have failed one or more lines of therapy


Sarah R. Blevins, PharmD, BCIDP, AAHIVP
University of Kentucky Healthcare, Bluegrass Care Clinic
Lexington, KY
Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and American Academy of HIV Medicine. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education
The Postgraduate Institute for Medicine designates this enduring material for a maximum of 2 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Pharmacy Education
Postgraduate Institute for Medicine designates this continuing education activity for 2 contact hour(s) (0.2 CEUs) of the Accreditation Council for Pharmacy Education (Universal Activity Number JA4008162-9999-20-2071-H02-P)
Type of Activity: Knowledge

Continuing Nursing Education
The maximum number of hours awarded for this Continuing Nursing Education activity is 1.9 contact hours. Designated for 0.8 contact hours of pharmacotherapy credit for Advanced Practice Registered Nurses.

Disclosure of Conflicts of Interest
Postgraduate Institute for Medicine (PIM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to PIM policy. PIM is committed to providing its learners with high quality activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.
Fee Information: There is no fee for this educational activity.

Method of Participation and Request for Credit:
There are no fees for participating and receiving CME/CE credit for this activity. During the period May 13, 2020 through May 13, 2021 participants must read the learning objectives and faculty disclosures and study the educational activity.

If you wish to receive acknowledgment for completing this activity, please complete the evaluation on On the navigation menu, click on “Find Post-test/Evaluation by Course” and search by course ID 15258. Upon registering and completing the activity evaluation, your certificate will be made available immediately.

For Pharmacists: Please complete the evaluation on On the navigation menu, click on “Find Post-test/Evaluation by Course” and search by course ID 15258. Upon successfully completing the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 4 weeks.

Hardware and Software Requirements
CME University requires a modern web browser (Internet Explorer 7+, Mozilla Firefox, Apple Safari, Google Chrome). Certain educational activities may require additional software to view multimedia, presentation, or printable versions of their content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Apple QuickTime, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, and Real Networks Real One Player.

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

This material is no longer available for CE. However, the slides are linked here for your review: FINAL AAHIVM HIV Resistance Slide Deck PDF