The term Pre-Exposure Prophylaxis (PrEP) refers to an HIV prevention practice in which persons not infected with HIV who are at high risk of the disease take antiretroviral medication in an attempt to lower their chances of becoming infected if exposed.
In May 2014, the Centers for Disease Control and Prevention (CDC) released final guidelines on the recommended use of PrEP. The guidelines recommend PrEP for HIV-uninfected patients with any of the following indications:
For sexually-active people, the guidelines also recommend that physicians encourage patients to use PrEP with other proven prevention strategies such as condoms to provide even greater protection than when used alone.
The new guidelines and clinical providers’ supplement are published in full at: “PrEP Guidelines 2014″ and “PrEP Provider Supplement 2014.”
In July 2012, the Food and Drug Administration (FDA) approved Truvada for the use of prevention of HIV in high-risk populations. The announcement signifies the approval of first medication available for PrEP in the United States.
In August 2012, the CDC released interim guidance for clinicians considering the use of daily oral antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV infection in their heterosexually active patients in the CDC’s Morbidity and Mortality Weekly Report (MMWR). The guidance complements the PrEP recommendations released in January 2011 for MSM and also provides guidance for heterosexual women and men, as well as a number of new recommendations for women of reproductive age and for couples in which one partner is HIV-positive and the other HIV-negative.
For more information on efforts around PrEP implementation in the United States, visit:
Centers for Disease Control and Prevention (CDC) Guideline Report on PrEP
CDC Interim Guidance on PrEP use in MSM